Contracting a disease weakens specific skills or attributes of your character. Disease effects remain active until cured with a potion or at a shrine, which can be found in most hold capitals. Unlike in Oblivion, there is no Cure Disease spell. One particularly notable and somewhat unique disease is Sanguinare Vampiris, which transforms your character into a vampire three days after contracting it if left untreated. Multiple disease effects stack together. Carrying a disease may cause NPCs to say that your character looks sickly or should go to bed, although Arcadia in Whiterun will say things like this even if your character is healthy.
There are a number of ways to contract diseases in Skyrim, perhaps most commonly by contact with a creature, animal, or even some NPCs. Most diseases can also be contracted through traps found outside throughout Skyrim or in various dungeons. For those diseases, the first ID in the following table is for the disease when caught from a creature, and the second ID is the trap-specific version. Although the physical effects of the two versions of the disease are the same, the descriptions are often slightly different.
|Ataxia||000b877c||Picking locks and picking pockets is 25% harder.||Skeever|
|0010a24a||Picking locks and picking pockets is 25% harder.||Traps|
|Black Heart BlightDB||xx01ff2e||Drains 10 points from Carry Weight.||None|
|Bone Break Fever||000b877e||Drains 25 points from Stamina.||Bear|
|0010a24c||Drains 25 points of Stamina.||Traps|
|Brain Rot||000b877f||Drains 25 points from Magicka.||Hagraven|
|0010a24d||Drains 25 points of Magicka.||Traps|
|DroopsDB||xx0285c1||One-handed and two-handed weapon damage is 15% lower.||Ash Hoppers|
|Rattles||000b8781||Stamina regenerates 50% more slowly.||Chaurus|
|0010a24e||Stamina regenerates 50% more slowly.||Traps|
|Rockjoint||000b8782||You are 25% less effective with melee weapons.||Fox, Wolf|
|0010a24f||You are 25% less effective with melee weapons.||Traps|
|Sanguinare Vampiris||000b8780||Reduces Health by 25. Progresses to Vampirism.||Vampires|
|Witbane||000b8783||Magicka regenerates 50% more slowly.||Sabre Cat|
|0010a250||Magicka regenerates 50% more slowly.||Traps|
- Argonians and Bosmer both have a constant Resist Disease 50% ability.
- Werewolves and vampires are both immune to disease.
- Spell Absorption provides protection against disease.
- Vigilants of Stendarr will cure diseases if asked to do so.
- Skyrim has the fewest amount of diseases in all Elder Scrolls Games besides Arena which has none.